The Best of Talking Heads é um álbum de grandes sucessos da banda de rock americana Talking Heads, lançado em 17 de agosto de 2004 pela Sire, Warner Bros. Records e Rhino Entertainment.

1. "Love → Building on Fire" Non-album single, 1977 2:58
2. "Psycho Killer" Byrne, Chris Frantz, Tina Weymouth Talking Heads: 77, 1977 4:20
3. "Uh-Oh, Love Comes to Town" Talking Heads: 77 2:50
4. "Take Me to the River" Al Green, Mabon "Teenie" Hodges More Songs About Buildings and Food, 1978 5:04
5. "Found a Job" More Songs About Buildings and Food 5:01
6. "Life During Wartime" Byrne, Frantz, Harrison, Weymouth Fear of Music, 1979 3:41
7. "Heaven" Byrne, Jerry Harrison Fear of Music 4:02
8. "Memories Can't Wait" Byrne, Harrison Fear of Music 3:31
9. "Once in a Lifetime" Byrne, Brian Eno, Frantz, Harrison, Weymouth Remain in Light, 1980 4:20
10. "Houses in Motion" Byrne, Eno, Frantz, Harrison, Weymouth Remain in Light 4:31
11. "This Must Be the Place (Naive Melody)" Byrne, Frantz, Harrison, Weymouth Speaking in Tongues, 1983 4:56
12. "Girlfriend Is Better" Byrne, Frantz, Harrison, Weymouth Speaking in Tongues 5:46
13. "Burning Down the House" Byrne, Frantz, Harrison, Weymouth Speaking in Tongues 4:03
14. "Road to Nowhere" Byrne, Frantz, Harrison, Weymouth Little Creatures, 1985 4:20
15. "And She Was" Little Creatures 3:39
16. "Wild Wild Life" True Stories, 1986 3:41
17. "Blind" Byrne, Frantz, Harrison, Weymouth Naked, 1988 5:00
18. "(Nothing But) Flowers" Byrne, Frantz, Harrison, Weymouth Naked 5:32